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Functional Rescue of Trafficking-Impaired ABCB4 Mutants by Chemical Chaperones
Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Null mutations in ABCB4 gene give rise to severe early-onset cholestatic liver disease. We have previously shown that the disease-associated mutations p.G68R, p.G...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764328/ https://ncbi.nlm.nih.gov/pubmed/26900700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150098 |
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