Effects of Cellular, Chemical, and Pharmacological Chaperones on the Rescue of a Trafficking-defective Mutant of the ATP-binding Cassette Transporter Proteins ABCB1/ABCB4

The ATP-binding cassette transporter ABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous to the multidrug transporter ABCB1. Variations in the ABCB4 gene sequence cause progressive familial intrahepatic cholestasis typ...

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Detalhes bibliográficos
Main Authors: Gautherot, Julien, Durand-Schneider, Anne-Marie, Delautier, Danièle, Delaunay, Jean-Louis, Rada, Alegna, Gabillet, Julie, Housset, Chantal, Maurice, Michèle, Aït-Slimane, Tounsia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281624/
https://ncbi.nlm.nih.gov/pubmed/22184139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275438
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