Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Over 150 mutations within the coding sequence of the V2 vasopressin receptor (V2R) gene are known to cause nephrogenic diabetes insipidus (NDI). A large number of these mutant receptors fail to fold properly and therefore are not routed to the cell surface. Here we show that selective, nonpeptidic V...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Morello, Jean-Pierre, Salahpour, Ali, Laperrière, André, Bernier, Virginie, Arthus, Marie-Françoise, Lonergan, Michèle, Petäjä-Repo, Ulla, Angers, Stéphane, Morin, Denis, Bichet, Daniel G., Bouvier, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC377482/
https://ncbi.nlm.nih.gov/pubmed/10749568
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados