Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Over 150 mutations within the coding sequence of the V2 vasopressin receptor (V2R) gene are known to cause nephrogenic diabetes insipidus (NDI). A large number of these mutant receptors fail to fold properly and therefore are not routed to the cell surface. Here we show that selective, nonpeptidic V...

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Hauptverfasser: Morello, Jean-Pierre, Salahpour, Ali, Laperrière, André, Bernier, Virginie, Arthus, Marie-Françoise, Lonergan, Michèle, Petäjä-Repo, Ulla, Angers, Stéphane, Morin, Denis, Bichet, Daniel G., Bouvier, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2000
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC377482/
https://ncbi.nlm.nih.gov/pubmed/10749568
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