Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Over 150 mutations within the coding sequence of the V2 vasopressin receptor (V2R) gene are known to cause nephrogenic diabetes insipidus (NDI). A large number of these mutant receptors fail to fold properly and therefore are not routed to the cell surface. Here we show that selective, nonpeptidic V...

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發表在:	J Clin Invest
Principais autores:	Morello, Jean-Pierre, Salahpour, Ali, Laperrière, André, Bernier, Virginie, Arthus, Marie-Françoise, Lonergan, Michèle, Petäjä-Repo, Ulla, Angers, Stéphane, Morin, Denis, Bichet, Daniel G., Bouvier, Michel
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 2000
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10749568/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8688
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