The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice

The B cell lymphoma 2 (Bcl-2) family member Bcl-xL has a well-characterized antiapoptotic function in lymphoid cells. However, its functions in other cells — including osteoclasts, which are of hematopoietic origin — and other cellular processes remain unknown. Here we report an unexpected function...

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Autori principali: Iwasawa, Mitsuyasu, Miyazaki, Tsuyoshi, Nagase, Yuichi, Akiyama, Toru, Kadono, Yuho, Nakamura, Masaki, Oshima, Yasushi, Yasui, Tetsuro, Matsumoto, Takumi, Nakamura, Takashi, Kato, Shigeaki, Hennighausen, Lothar, Nakamura, Kozo, Tanaka, Sakae
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755133/
https://ncbi.nlm.nih.gov/pubmed/19759519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39819
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