Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast

Signal transducer and activator of transcription 5 (Stat5) is essential for cytokine-regulated processes such as proliferation, differentiation, and survival in hematopoietic cells. To investigate the role of Stat5 in osteoclasts, we generated mice with an osteoclast-specific conditional deletion of...

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Hauptverfasser: Hirose, Jun, Masuda, Hironari, Tokuyama, Naoto, Omata, Yasunori, Matsumoto, Takumi, Yasui, Tetsuro, Kadono, Yuho, Hennighausen, Lothar, Tanaka, Sakae
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892975/
https://ncbi.nlm.nih.gov/pubmed/24367002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130538
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