Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mut...

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Detalhes bibliográficos
Main Authors: Sakai, Wataru, Swisher, Elizabeth M., Jacquemont, Céline, Chandramohan, Kurapaty Venkatapoorna, Couch, Fergus J., Langdon, Simon P., Wurz, Kaitlyn, Higgins, Jake, Villegas, Emily, Taniguchi, Toshiyasu
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754824/
https://ncbi.nlm.nih.gov/pubmed/19654294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1178
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