Codon Stabilization Analysis of the “248” Temperature Sensitive Mutation for Increased Phenotypic Stability of Respiratory Syncytial Virus Vaccine Candidates

Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory tract illness worldwide. Presently, the most promising vaccine candidate is a live, attenuated, cDNA-derived virus, RSV rA2cp248/404/1030ΔSH, whose attenuation phenotype is based in large part...

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Detalhes bibliográficos
Main Authors: Luongo, Cindy, Yang, Lijuan, Winter, Christine C., Spann, Kirsten M., Murphy, Brian R., Collins, Peter L., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754210/
https://ncbi.nlm.nih.gov/pubmed/19646406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.07.022
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