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Respiratory Syncytial Virus Modified by Deletions of the NS2 Gene and Amino Acid S1313 of the L Polymerase Protein Is a Temperature-Sensitive, Live-Attenuated Vaccine Candidate That Is Phenotypically Stable at Physiological Temperature

Human respiratory syncytial virus (RSV) is the leading viral cause of lower respiratory tract disease in infants and children worldwide. In previous work to develop point mutations in RSV with improved genetic stability, we observed that an attenuating mutation at amino acid position 1321 in the L p...

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書目詳細資料
Main Authors: Luongo, Cindy, Winter, Christine C., Collins, Peter L., Buchholz, Ursula J.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571493/
https://ncbi.nlm.nih.gov/pubmed/23236065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02769-12
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