Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F

The bacterial metabolite kinamycin F, which is being investigated as a potent antitumor agent, contains an unusual and potentially reactive diazo group as well as a paraquinone and a phenol functional group. Kinamycin F reacted with glutathione (GSH) in a complex series of reactions which suggested...

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Detalhes bibliográficos
Main Authors: O’Hara, Kimberley A., Wu, Xing, Patel, Daywin, Liang, Hong, Yalowich, Jack C., Chen, Nan, Goodfellow, Valery, Adedayo, Otunola, Dmitrienko, Gary I., Hasinoff, Brian B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753228/
https://ncbi.nlm.nih.gov/pubmed/17854709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.07.005
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