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Synthesis and SAR of a Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 4 (mGluR4)

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a n...

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Autors principals: Williams, Richard, Johnson, Kari A., Gentry, Patrick R., Niswender, Colleen M., Weaver, Charles D., Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752865/
https://ncbi.nlm.nih.gov/pubmed/19640716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.07.072
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