Vaccination with a Defined Francisella tularensis subsp. novicida Pathogenicity Island Mutant (ΔiglB) Induces Protective Immunity Against Homotypic and Heterotypic Challenge

Francisella tularensis, an intracellular Gram-negative bacterium, is the causative agent of tularemia and a potential bioweapon. Currently, there is no licensed vaccine against this organism. We have characterized the efficacy of a defined F. tularensis subsp. novicida mutant (ΔiglB) as a live atten...

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Hauptverfasser: Cong, Yu, Yu, Jieh-Juen, Guentzel, M. Neal, Berton, Michael T., Seshu, Janakiram, Klose, Karl E., Arulanandam, Bernard P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752818/
https://ncbi.nlm.nih.gov/pubmed/19651173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.07.034
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