Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

Interindividual variability in response to chemicals and drugs is a common regulatory concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic basis, but many mechanism-based investigations have not been successful in identifying susceptible individuals. While recent ad...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Harrill, Alison H., Watkins, Paul B., Su, Stephen, Ross, Pamela K., Harbourt, David E., Stylianou, Ioannis M., Boorman, Gary A., Russo, Mark W., Sackler, Richard S., Harris, Stephen C., Smith, Philip C., Tennant, Raymond, Bogue, Molly, Paigen, Kenneth, Harris, Christopher, Contractor, Tanupriya, Wiltshire, Timothy, Rusyn, Ivan, Threadgill, David W.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Cold Spring Harbor Laboratory Press 2009
Θέματα:
Letter
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752130/
https://ncbi.nlm.nih.gov/pubmed/19416960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.090241.108
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