Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

Interindividual variability in response to chemicals and drugs is a common regulatory concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic basis, but many mechanism-based investigations have not been successful in identifying susceptible individuals. While recent ad...

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Detalhes bibliográficos
Main Authors: Harrill, Alison H., Watkins, Paul B., Su, Stephen, Ross, Pamela K., Harbourt, David E., Stylianou, Ioannis M., Boorman, Gary A., Russo, Mark W., Sackler, Richard S., Harris, Stephen C., Smith, Philip C., Tennant, Raymond, Bogue, Molly, Paigen, Kenneth, Harris, Christopher, Contractor, Tanupriya, Wiltshire, Timothy, Rusyn, Ivan, Threadgill, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752130/
https://ncbi.nlm.nih.gov/pubmed/19416960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.090241.108
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