Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

Interindividual variability in response to chemicals and drugs is a common regulatory concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic basis, but many mechanism-based investigations have not been successful in identifying susceptible individuals. While recent ad...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Harrill, Alison H., Watkins, Paul B., Su, Stephen, Ross, Pamela K., Harbourt, David E., Stylianou, Ioannis M., Boorman, Gary A., Russo, Mark W., Sackler, Richard S., Harris, Stephen C., Smith, Philip C., Tennant, Raymond, Bogue, Molly, Paigen, Kenneth, Harris, Christopher, Contractor, Tanupriya, Wiltshire, Timothy, Rusyn, Ivan, Threadgill, David W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2009
विषय:
Letter
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752130/
https://ncbi.nlm.nih.gov/pubmed/19416960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.090241.108
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