Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

ER stress–induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture and in vivo mouse models of ER stress–induced apoptosis, we have shown that cytoso...

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Hauptverfasser: Timmins, Jenelle M., Ozcan, Lale, Seimon, Tracie A., Li, Gang, Malagelada, Cristina, Backs, Johannes, Backs, Thea, Bassel-Duby, Rhonda, Olson, Eric N., Anderson, Mark E., Tabas, Ira
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752072/
https://ncbi.nlm.nih.gov/pubmed/19741297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38857
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