Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

ER stress–induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture and in vivo mouse models of ER stress–induced apoptosis, we have shown that cytoso...

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Bibliografiske detaljer
Main Authors: Timmins, Jenelle M., Ozcan, Lale, Seimon, Tracie A., Li, Gang, Malagelada, Cristina, Backs, Johannes, Backs, Thea, Bassel-Duby, Rhonda, Olson, Eric N., Anderson, Mark E., Tabas, Ira
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752072/
https://ncbi.nlm.nih.gov/pubmed/19741297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38857
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