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Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis

Thymocytes lacking adenosine deaminase (ADA) activity, a purine metabolism enzyme, accumulate intracellular dATP and consequently undergo apoptosis during development. We have analyzed the effect of ADA enzyme inhibition in human thymocyte suspension cultures with regard to accumulation of intracell...

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Bibliografische gegevens
Hoofdauteurs: Joachims, Michelle L, Marble, Patrick, Knott-Craig, Christopher, Pastuszko, Peter, Blackburn, Michael R, Thompson, Linda F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752032/
https://ncbi.nlm.nih.gov/pubmed/18600545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770802146270
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