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Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis
Thymocytes lacking adenosine deaminase (ADA) activity, a purine metabolism enzyme, accumulate intracellular dATP and consequently undergo apoptosis during development. We have analyzed the effect of ADA enzyme inhibition in human thymocyte suspension cultures with regard to accumulation of intracell...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752032/ https://ncbi.nlm.nih.gov/pubmed/18600545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770802146270 |
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