Restoration of adenosine deaminase-deficient human thymocyte development in vitro by inhibition of deoxynucleoside kinases,

Mutations in the gene encoding adenosine deaminase (ADA), a purine salvage enzyme, lead to immunodeficiency in humans. Although ADA deficiency has been analyzed in cell culture and murine models, information is lacking concerning its impact on the development of human thymocytes. We have used chimer...

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Bibliographic Details
Main Authors: Joachims, Michelle L., Marble, Patrick A., Laurent, Aletha B., Pastuszko, Peter, Paliotta, Marco, Blackburn, Michael R., Thompson, Linda F.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673198/
https://ncbi.nlm.nih.gov/pubmed/19018008
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