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Further Differentiation of Murine Double Positive Thymocytes Is Inhibited in Adenosine Deaminase-Deficient Murine Fetal Thymic Organ Culture

Murine fetal thymic organ culture (FTOC) was used to investigate the mechanism by which a lack of adenosine deaminase (ADA) leads to a failure of T cell production in the thymus. We previously showed that T cell development was inhibited beginning at the CD4(−)CD8(−)CD25(+)CD44(lo) stage in ADA-defi...

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Bibliografiske detaljer
Main Authors: Van De Wiele, C. Justin, Joachims, Michelle L., Fesler, Amy M., Vaughn, James G., Blackburn, Michael R., McGee, Stephanie T., Thompson, Linda F.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550651/
https://ncbi.nlm.nih.gov/pubmed/16670300
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