CYP1A1 and CYP1A2 expression: Comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

Human and rodent cytochrome P450 (CYP) enzymes sometimes exhibit striking species-specific differences in substrate preference and rate of metabolism. Human risk assessment of CYP substrates might therefore best be evaluated in the intact mouse by replacing mouse Cyp genes with human CYP orthologs;...

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Bibliographische Detailangaben
Hauptverfasser: Uno, Shigeyuki, Endo, Kaori, Ishida, Yuji, Tateno, Chise, Makishima, Makoto, Yoshizato, Katsutoshi, Nebert, Daniel W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752030/
https://ncbi.nlm.nih.gov/pubmed/19285097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.03.001
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