CYP1A1 and CYP1A2 expression: Comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

Human and rodent cytochrome P450 (CYP) enzymes sometimes exhibit striking species-specific differences in substrate preference and rate of metabolism. Human risk assessment of CYP substrates might therefore best be evaluated in the intact mouse by replacing mouse Cyp genes with human CYP orthologs;...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Uno, Shigeyuki, Endo, Kaori, Ishida, Yuji, Tateno, Chise, Makishima, Makoto, Yoshizato, Katsutoshi, Nebert, Daniel W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752030/
https://ncbi.nlm.nih.gov/pubmed/19285097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.03.001
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky