Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice

Por Uno, Shigeyuki, Nebert, Daniel W., Makishima, Makoto
Publicado no Food Chem Toxicol (2018)

Generation of ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−) mouse line

Por Dragin, Nadine, Uno, Shigeyuki, Wang, Bin, Dalton, Timothy P., Nebert, Daniel W.
Publicado em 2007

Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1 Knockout Mouse Lines as a Paradigm

Por Nebert, Daniel W., Shi, Zhanquan, Gálvez-Peralta, Marina, Uno, Shigeyuki, Dragin, Nadine
Publicado em 2013

CYP1A1 and CYP1A2 expression: Comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

Por Uno, Shigeyuki, Endo, Kaori, Ishida, Yuji, Tateno, Chise, Makishima, Makoto, Yoshizato, Katsutoshi, Nebert, Daniel W.
Publicado em 2009

Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract

Por Uno, Shigeyuki, Dragin, Nadine, Miller, Marian L., Dalton, Timothy P., Gonzalez, Frank J., Nebert, Daniel W.
Publicado em 2007

Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice

Por Ozeki, Jun, Uno, Shigeyuki, Ogura, Michitaka, Choi, Mihwa, Maeda, Tetsuyo, Sakurai, Kenichi, Matsuo, Sadanori, Amano, Sadao, Nebert, Daniel W., Makishima, Makoto
Publicado em 2010

Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

Por Dong, Hongbin, Dalton, Timothy P., Miller, Marian L., Chen, Ying, Uno, Shigeyuki, Shi, Zhanquan, Shertzer, Howard G., Bansal, Seema, Avadhani, Narayan G., Nebert, Daniel W.
Publicado em 2009

Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype

Por Shi, Zhanquan, Dragin, Nadine, Miller, Marian L., Stringer, Keith F., Johansson, Elisabet, Chen, Jing, Uno, Shigeyuki, Gonzalez, Frank J., Rubio, Carlos A., Nebert, Daniel W.
Publicado em 2010

RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists

Por Kakuta, Hiroki, Yakushiji, Nobumasa, Shinozaki, Ryosuke, Ohsawa, Fuminori, Yamada, Shoya, Ohta, Yui, Kawata, Kohei, Nakayama, Mariko, Hagaya, Manabu, Fujiwara, Chisa, Makishima, Makoto, Uno, Shigeyuki, Tai, Akihiro, Maehara, Ami, Nakayama, Masaru, Oohashi, Toshitaka, Yasui, Hiroyuki, Yoshikawa, Yutaka
Publicado em 2012