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Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice

The Western diet contributes to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Benzo[a]pyrene (BaP), a prototypical environmental pollutant produced by combustion processes, is present in charcoal-grilled meat. Cytochrome P450 1A1 (CYP1A1) metabolizes BaP, resulting in either detoxication or...

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Détails bibliographiques
Publié dans:Food Chem Toxicol
Auteurs principaux: Uno, Shigeyuki, Nebert, Daniel W., Makishima, Makoto
Format: Artigo
Langue:Inglês
Publié: 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831517/
https://ncbi.nlm.nih.gov/pubmed/29366871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2018.01.029
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