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Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice

The environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) is known to cause a wide variety of toxic effects, including hepatotoxicity, by way of the aryl hydrocarbon receptor (AHR). Although inducible expression of cytochrome P450 (CYP) 1A1 and CYP1A2 is associated with liver injury ca...

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Detalhes bibliográficos
Main Authors: Ozeki, Jun, Uno, Shigeyuki, Ogura, Michitaka, Choi, Mihwa, Maeda, Tetsuyo, Sakurai, Kenichi, Matsuo, Sadanori, Amano, Sadao, Nebert, Daniel W., Makishima, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011047/
https://ncbi.nlm.nih.gov/pubmed/21095216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2010.11.003
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