Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice

The environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) is known to cause a wide variety of toxic effects, including hepatotoxicity, by way of the aryl hydrocarbon receptor (AHR). Although inducible expression of cytochrome P450 (CYP) 1A1 and CYP1A2 is associated with liver injury ca...

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Bibliografiske detaljer
Main Authors: Ozeki, Jun, Uno, Shigeyuki, Ogura, Michitaka, Choi, Mihwa, Maeda, Tetsuyo, Sakurai, Kenichi, Matsuo, Sadanori, Amano, Sadao, Nebert, Daniel W., Makishima, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011047/
https://ncbi.nlm.nih.gov/pubmed/21095216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2010.11.003
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