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Generation of ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−) mouse line
Human/rodent CYP1A1 and CYP1A2 orthologs are well known to exhibit species-specific differences in substrate preferences and rates of metabolism. This lab previously characterized a BAC-transgenic mouse carrying the human CYP1A1_CYP1A2 locus; in this line, human dioxin-inducible CYP1A1 and basal vs...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1994648/ https://ncbi.nlm.nih.gov/pubmed/17560947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.05.202 |
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