Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

In the past, CYP1A1 protein was known to be located in the endoplasmic reticulum (ER; microsomes). More recently, CYP1A1 was shown also to be targeted to the inner mitochondrial membrane; mitochondrial import is dependent on NH(2)-terminal processing that exposes a cryptic targeting signal. It is in...

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Main Authors: Dong, Hongbin, Dalton, Timothy P., Miller, Marian L., Chen, Ying, Uno, Shigeyuki, Shi, Zhanquan, Shertzer, Howard G., Bansal, Seema, Avadhani, Narayan G., Nebert, Daniel W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684908/
https://ncbi.nlm.nih.gov/pubmed/19047483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.051888
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