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Characterization of the NAD(P)H Oxidase and Metronidazole Reductase Activities of the RdxA Nitroreductase of Helicobacter pylori

Metronidazole (MTZ) is widely used in combination therapies against the human gastric pathogen Helicobacter pylori. Resistance to this drug is common among clinical isolates and results from loss of function mutations in rdxA, which encodes an oxygen insensitive nitroreductase (NTR). The RdxA-associ...

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Bibliografski detalji
Glavni autori: Olekhnovich, Igor N., Goodwin, Avery, Hoffman, Paul S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751797/
https://ncbi.nlm.nih.gov/pubmed/19438716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07060.x
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