Structure of RdxA: an oxygen insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori

The RdxA oxygen insensitive nitroreductase of the human gastric pathogen Helicobacter pylori is responsible for the susceptibility of this organism to the redox active prodrug metronidazole (MTZ). Loss-of-function mutations in rdxA are primarily responsible for resistance to this therapeutic. RdxA e...

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Hauptverfasser: Martínez-Júlvez, Marta, Rojas, Adriana L., Olekhnovich, Igor, Angarica, Vladimir Espinosa, Hoffman, Paul S., Sancho, Javier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504637/
https://ncbi.nlm.nih.gov/pubmed/23039228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12020
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