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Structure of RdxA: an oxygen insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori
The RdxA oxygen insensitive nitroreductase of the human gastric pathogen Helicobacter pylori is responsible for the susceptibility of this organism to the redox active prodrug metronidazole (MTZ). Loss-of-function mutations in rdxA are primarily responsible for resistance to this therapeutic. RdxA e...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504637/ https://ncbi.nlm.nih.gov/pubmed/23039228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12020 |
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