SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

The physiological function of Sentrin/SUMO-specific proteases (SENPs) remains largely unexplored, and little is known about the regulation of SENPs themselves. Here, we show that a modest increase of reactive oxygen species (ROS) regulates SENP3 stability and localization. We found that SENP3 is con...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Huang, Chao, Han, Yan, Wang, Yumei, Sun, Xuxu, Yan, Shan, Yeh, Edward T H, Chen, Yuying, Cang, Hui, Li, Hui, Shi, Guiying, Cheng, Jinke, Tang, Xueming, Yi, Jing
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750016/
https://ncbi.nlm.nih.gov/pubmed/19680224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.210
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