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SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein

Amyloid β, a key molecule in the pathogenesis of Alzheimer's disease (AD), is produced from amyloid precursor protein (APP) by the cleavage of secretases. APP is SUMOylated near the cleavage site of β-secretase. SUMOylation of APP reduces amyloid β production, but its regulatory system is still...

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Detalhes bibliográficos
Publicado no:Heliyon
Main Authors: Maruyama, Takuma, Abe, Yoichiro, Niikura, Takako
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968171/
https://ncbi.nlm.nih.gov/pubmed/29862363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00601
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