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SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein
Amyloid β, a key molecule in the pathogenesis of Alzheimer's disease (AD), is produced from amyloid precursor protein (APP) by the cleavage of secretases. APP is SUMOylated near the cleavage site of β-secretase. SUMOylation of APP reduces amyloid β production, but its regulatory system is still...
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| Izdano u: | Heliyon |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5968171/ https://ncbi.nlm.nih.gov/pubmed/29862363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e00601 |
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