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Association of Genotypes of the CYP3A Cluster with Midazolam Disposition In Vivo

The genes that encode for CYP3A4 and CYP3A5 are located in the same region (CYP3A cluster) on chromosome 7. Midazolam (MDZ) is a substrate for both CYP3A4 and CYP3A5. We hypothesize that MDZ disposition in vivo is associated with genotypes of the CYP3A cluster. A meta-analysis of the pharmacokinetic...

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Detalhes bibliográficos
Main Authors: Miao, Jia, Jin, Yan, Marunde, Rita L., Kim, Seongho, Quinney, Sara, Radovich, Milan, Li, Lang, Hall, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749890/
https://ncbi.nlm.nih.gov/pubmed/19506580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2009.21
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