Association of Genotypes of the CYP3A Cluster with Midazolam Disposition In Vivo

The genes that encode for CYP3A4 and CYP3A5 are located in the same region (CYP3A cluster) on chromosome 7. Midazolam (MDZ) is a substrate for both CYP3A4 and CYP3A5. We hypothesize that MDZ disposition in vivo is associated with genotypes of the CYP3A cluster. A meta-analysis of the pharmacokinetic...

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Bibliographic Details
Main Authors: Miao, Jia, Jin, Yan, Marunde, Rita L., Kim, Seongho, Quinney, Sara, Radovich, Milan, Li, Lang, Hall, Stephen D.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749890/
https://ncbi.nlm.nih.gov/pubmed/19506580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2009.21
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