Integration of In Vitro Binding Mechanism Into the Semiphysiologically Based Pharmacokinetic Interaction Model Between Ketoconazole and Midazolam

In vitro screening for drug–drug interactions is an integral component of drug development, with larger emphasis now placed on the use of in vitro parameters to predict clinical inhibition. However, large variability exists in K(i) reported for ketoconazole with midazolam, a model inhibitor–substrat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Quinney, Sara K., Knopp, Shawn, Chang, Chien, Hall, Stephen D., Li, Lang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026634/
https://ncbi.nlm.nih.gov/pubmed/24448021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.50
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