Integration of In Vitro Binding Mechanism Into the Semiphysiologically Based Pharmacokinetic Interaction Model Between Ketoconazole and Midazolam

In vitro screening for drug–drug interactions is an integral component of drug development, with larger emphasis now placed on the use of in vitro parameters to predict clinical inhibition. However, large variability exists in K(i) reported for ketoconazole with midazolam, a model inhibitor–substrat...

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Bibliografiske detaljer
Main Authors: Quinney, Sara K., Knopp, Shawn, Chang, Chien, Hall, Stephen D., Li, Lang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026634/
https://ncbi.nlm.nih.gov/pubmed/24448021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.50
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