Pharmacokinetic interaction of riociguat with ketoconazole, clarithromycin, and midazolam

Abstract. Riociguat is a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension that is principally metabolized via the cytochrome P450 (CYP) pathway. Three studies in healthy males investigated potential pharmacokinetic interactions between riociguat and CYP inhibitors (ke...

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Bibliografiske detaljer
Udgivet i:Pulm Circ
Main Authors: Becker, Corina, Frey, Reiner, Unger, Sigrun, Thomas, Dirk, Reber, Michael, Weimann, Gerrit, Dietrich, Hartmut, Arens, Erich R., Mück, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: University of Chicago Press 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860537/
https://ncbi.nlm.nih.gov/pubmed/27162627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/685016
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