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Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption
Abstract. Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect o...
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| Published in: | Pulm Circ |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
University of Chicago Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860530/ https://ncbi.nlm.nih.gov/pubmed/27162626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/682228 |
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