Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption

Abstract. Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect o...

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Bibliographic Details
Published in:Pulm Circ
Main Authors: Becker, Corina, Frey, Reiner, Unger, Sigrun, Artmeier-Brandt, Ulrike, Weimann, Gerrit, Mück, Wolfgang
Format: Artigo
Language:Inglês
Published: University of Chicago Press 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860530/
https://ncbi.nlm.nih.gov/pubmed/27162626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/682228
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