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Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption

Abstract. Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect o...

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Bibliografiska uppgifter
I publikationen:Pulm Circ
Huvudupphovsmän: Becker, Corina, Frey, Reiner, Unger, Sigrun, Artmeier-Brandt, Ulrike, Weimann, Gerrit, Mück, Wolfgang
Materialtyp: Artigo
Språk:Inglês
Publicerad: University of Chicago Press 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860530/
https://ncbi.nlm.nih.gov/pubmed/27162626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/682228
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