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Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption

Abstract. Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect o...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pulm Circ
Auteurs principaux: Becker, Corina, Frey, Reiner, Unger, Sigrun, Artmeier-Brandt, Ulrike, Weimann, Gerrit, Mück, Wolfgang
Format: Artigo
Langue:Inglês
Publié: University of Chicago Press 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860530/
https://ncbi.nlm.nih.gov/pubmed/27162626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/682228
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