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Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption

Abstract. Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pulm Circ
Prif Awduron: Becker, Corina, Frey, Reiner, Unger, Sigrun, Artmeier-Brandt, Ulrike, Weimann, Gerrit, Mück, Wolfgang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: University of Chicago Press 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860530/
https://ncbi.nlm.nih.gov/pubmed/27162626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/682228
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