Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat

Oral riociguat is a soluble guanylate cyclase (sGC) stimulator that targets the nitric oxide (NO)–sGC–cyclic guanosine monophosphate pathway with a dual mode of action: directly by stimulating sGC, and indirectly by increasing the sensitivity of sGC to NO. It is rapidly absorbed, displays almost com...

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Sparad:
Bibliografiska uppgifter
I publikationen:Clin Pharmacokinet
Huvudupphovsmän: Frey, Reiner, Becker, Corina, Saleh, Soundos, Unger, Sigrun, van der Mey, Dorina, Mück, Wolfgang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2017
Ämnen:
Review Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974002/
https://ncbi.nlm.nih.gov/pubmed/29086344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0604-7
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