Interaction between midazolam and clarithromycin in the elderly

AIM: To assess the relative contribution of intestinal and hepatic CYP3A inhibition to the interaction between the prototypic CYP3A substrate midazolam and clarithromycin in the elderly. METHODS: On day 1, 16 volunteers (eight male, eight female) aged 65–75 years weighing 59–112 kg received simultan...

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Detaylı Bibliyografya
Asıl Yazarlar: Quinney, Sara K, Haehner, Barbara D, Rhoades, Melissa B, Lin, Zhen, Gorski, J Christopher, Hall, Stephen D
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2008
Konular:
Drug Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291277/
https://ncbi.nlm.nih.gov/pubmed/17635500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02970.x
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