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Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin
AIMS: To determine the extent and time-course of hepatic and intestinal cytochrome P450 3A (CYP3A) inactivation due to the mechanism-based inhibitor clarithromycin. METHODS: Intestinal and hepatic CYP3A inhibition was examined in 12 healthy volunteers following the administration of single and multi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712509/ https://ncbi.nlm.nih.gov/pubmed/22777148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-012-1339-x |
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