Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination

A heterologous prime-boost strategy using plasmid DNA, followed by replication-defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4(+) and CD8(+) T-cell-mediated protective immunity against intracellular pathogens. We confirmed this concept and furthered existing res...

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Autori principali: de Alencar, Bruna C. G., Persechini, Pedro M., Haolla, Filipe A., de Oliveira, Gabriel, Silverio, Jaline C., Lannes-Vieira, Joseli, Machado, Alexandre V., Gazzinelli, Ricardo T., Bruna-Romero, Oscar, Rodrigues, Mauricio M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747960/
https://ncbi.nlm.nih.gov/pubmed/19651871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01459-08
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