CD8(+) T-Cells Expressing Interferon Gamma or Perforin Play Antagonistic Roles in Heart Injury in Experimental Trypanosoma Cruzi-Elicited Cardiomyopathy

In Chagas disease, CD8(+) T-cells are critical for the control of Trypanosoma cruzi during acute infection. Conversely, CD8(+) T-cell accumulation in the myocardium during chronic infection may cause tissue injury leading to chronic chagasic cardiomyopathy (CCC). Here we explored the role of CD8(+)...

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Autores principales: Silverio, Jaline Coutinho, Pereira, Isabela Resende, Cipitelli, Márcio da Costa, Vinagre, Nathália Ferreira, Rodrigues, Maurício Martins, Gazzinelli, Ricardo Tostes, Lannes-Vieira, Joseli
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330123/
https://ncbi.nlm.nih.gov/pubmed/22532799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002645
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