A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent

A new human, compact antibody was engineered by fusion of a human, antitumour ErbB2-directed scFv with a human IgG1 Fc domain. Overexpression of the ErbB2 receptor is related to tumour aggressiveness and poor prognosis. This new immunoagent meets all criteria for a potential anticancer drug: it is h...

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Bibliographic Details
Main Authors: De Lorenzo, C, Tedesco, A, Terrazzano, G, Cozzolino, R, Laccetti, P, Piccoli, R, D'Alessio, G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747711/
https://ncbi.nlm.nih.gov/pubmed/15305184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602110
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