An anti-ErbB2 fully human antibody circumvents trastuzumab resistance

Trastuzumab, an anti-HER2/ErbB2 humanized antibody, has shown great clinical benefits in ErbB2-positive breast cancer treatment. Despite of its effectiveness, response rate to trastuzumab is limited and resistance is common. Here, we developed a new anti-ErbB2 antibody, denoted as H2-18, which was i...

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Опубликовано в: :Oncotarget
Главные авторы: Lu, Qiong, Wang, Lingfei, Zhang, Yajun, Yu, Xiaojie, Wang, Chao, Wang, Huajing, Yang, Yang, Chong, Xiaodan, Xia, Tian, Meng, Yanchun, Wang, Yuxiao, Lu, Cuihua, Zhou, Lijun, Li, Bohua
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341862/
https://ncbi.nlm.nih.gov/pubmed/27564098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11562
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