Antitumour effects of PLC-γ1-(SH2)(2)-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells

Due to its pivotal role in the growth factor-mediated tumour cell migration, the adaptor protein phospholipase C-γ1 (PLC-γ1) is an appropriate target to block ultimately the spreading of EGFR/c-erbB-2-positive tumour cells, thereby minimising metastasis formation. Here, we present an approach to blo...

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Autori principali: Katterle, Y, Brandt, B H, Dowdy, S F, Niggemann, B, Zänker, K S, Dittmar, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395298/
https://ncbi.nlm.nih.gov/pubmed/14710234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601506
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