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Caffeine Induces Ca(2+) Release by Reducing The Threshold for Luminal Ca(2+) Activation of the Ryanodine Receptor
Caffeine has long been used as a pharmacological probe for studying ryanodine receptor (RyR)-mediated Ca(2+) release and cardiac arrhythmias. However, the precise mechanism by which caffeine activates RyRs is elusive. Here we investigated the effects of caffeine on spontaneous Ca(2+) release and on...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747660/ https://ncbi.nlm.nih.gov/pubmed/18518861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080489 |
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