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Synthesis and structure-activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters
[Image: see text] Early studies led to the identification of 3β-(4-methoxyphenyl)tropane-2β-carboxylic acid methyl ester (5) with high affinity at the DAT (IC(50) = 6.5 nM) and 5-HTT (K(i) = 4.3 nM), while having much less affinity at the NET (K(i) = 1110 nM). In the present study, we replaced the 4...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747657/ https://ncbi.nlm.nih.gov/pubmed/19523837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.052 |
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