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Dynamic Cycling with Hsp90 Stabilizes Neuronal Nitric Oxide Synthase Through Calmodulin-dependent Inhibition of Ubiquitination

NO production by neuronal nitric oxide synthase (nNOS) requires calmodulin and is enhanced by the chaperone Hsp90, which cycles dynamically with the enzyme. The proteasomal degradation of nNOS is enhanced by suicide inactivation and by treatment with Hsp90 inhibitors, the latter suggesting that dyna...

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Detaylı Bibliyografya
Asıl Yazarlar: Peng, Hwei-Ming, Morishima, Yoshihiro, Clapp, Kelly M., Lau, Miranda, Pratt, William B., Osawa, Yoichi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747607/
https://ncbi.nlm.nih.gov/pubmed/19642705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901058g
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