Synthesis and Evaluation of an RNA Editing Substrate Bearing 2’-Deoxy-2’-mercaptoadenosine

The RNA-editing adenosine deaminases (ADARs) catalyze deamination of adenosine to inosine in double stranded structure found in various RNA substrates, including mRNAs. Here we describe the synthesis of a phosphoramidite of 2’-deoxy-2'-mercaptoadenosine and its incorporation into an ADAR substr...

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Bibliographic Details
Main Authors: Jayalath, Prasanna, Pokharel, Subhash, Véliz, Eduardo, Beal, Peter A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747504/
https://ncbi.nlm.nih.gov/pubmed/19219738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770902736459
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