Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis lymphatic valve leaflet formation is initiated by upregulation of integrin-α9 expression and deposition of its ligand, fibronectin-EIIIA (F...

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Autori principali: Bazigou, Eleni, Xie, Sherry, Chen, Chun, Weston, Anne, Miura, Naoyuki, Sorokin, Lydia, Adams, Ralf, Muro, Andrés F., Sheppard, Dean, Makinen, Taija
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747264/
https://ncbi.nlm.nih.gov/pubmed/19686679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.06.017
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