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Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis lymphatic valve leaflet formation is initiated by upregulation of integrin-α9 expression and deposition of its ligand, fibronectin-EIIIA (F...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747264/ https://ncbi.nlm.nih.gov/pubmed/19686679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.06.017 |
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